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pentobarbital will reduce the level or impact of parecoxib by influencing hepatic enzyme CYP2C9/10 metabolism. Use Warning/Keep track of.pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can lessen panobinostat amounts by ~70% and result in procedure fai